Rapid HPLC Measurement of Thiamine and Its Phosphate Esters in Whole Blood
Author(s) -
Jun Lü,
Elizabeth L. Frank
Publication year - 2008
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2007.099077
Subject(s) - thiamine , chromatography , chemistry , vitamin , whole blood , potassium ferricyanide , high performance liquid chromatography , population , detection limit , b vitamins , biochemistry , endocrinology , medicine , environmental health , organic chemistry
Thiamine (vitamin B(1)) deficiency is associated with severe diseases such as beriberi and Wernicke encephalopathy. Although most Americans have sufficient dietary intake, thiamine deficiency is observed in the alcohol-dependent and elderly populations. Measurement of thiamine concentration in whole blood provides an assessment of vitamin B(1) status in at-risk individuals.
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