Haptoglobin Polymorphism: A Novel Genetic Risk Factor for Celiac Disease Development and Its Clinical Manifestations | Zendy

Mária Papp | Zendy; Ildikó Földi | Zendy; Éva Nemes | Zendy; M. Udvardy | Zendy; Jolán Hársfalvi | Zendy; I Altorjay | Zendy; István Máté | Zendy; Tamás Dinya | Zendy; Csaba Várvölgyi | Zendy; Zsolt Barta | Zendy; Gábor Veres | Zendy; Péter L. Lakatos | Zendy; Judit Tumpek | Zendy; László Tóth | Zendy; Erzsébet Szathmári | Zendy; Anikó Kapitány | Zendy; Ãgnes Gyetvai | Zendy; Ilma R. Korponay–Szabó | Zendy

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Haptoglobin Polymorphism: A Novel Genetic Risk Factor for Celiac Disease Development and Its Clinical Manifestations

Author(s) -

Mária Papp,

Ildikó Földi,

Éva Nemes,

M. Udvardy,

Jolán Hársfalvi,

I Altorjay,

István Máté,

Tamás Dinya,

Csaba Várvölgyi,

Zsolt Barta,

Gábor Veres,

Péter L. Lakatos,

Judit Tumpek,

László Tóth,

Erzsébet Szathmári,

Anikó Kapitány,

Ãgnes Gyetvai,

Ilma R. Korponay–Szabó

Publication year - 2008

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2007.098780

Subject(s) - haptoglobin , dermatitis herpetiformis , gastroenterology , medicine , malabsorption , genotype , immunology , disease , odds ratio , biology , genetics , gene

Haptoglobin (Hp) alpha-chain alleles 1 and 2 account for 3 phenotypes that may influence the course of inflammatory diseases via biologically important differences in their antioxidant, scavenging, and immunomodulatory properties. Hp1-1 genotype results in the production of small dimeric, Hp2-1 linear, and Hp2-2 cyclic polymeric haptoglobin molecules. We investigated the haptoglobin polymorphism in patients with celiac disease and its possible association to the presenting symptoms.

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