Rapid and Sensitive Detection of BRCA1/2 Mutations in a Diagnostic Setting: Comparison of Two High-Resolution Melting Platforms | Zendy

Kim De Leeneer | Zendy; Ilse Coene | Zendy; Bruce Poppe | Zendy; Anne De Paepe | Zendy; Kathleen Claes | Zendy

Open Access

Rapid and Sensitive Detection of BRCA1/2 Mutations in a Diagnostic Setting: Comparison of Two High-Resolution Melting Platforms

Author(s) -

Kim De Leeneer,

Ilse Coene,

Bruce Poppe,

Anne De Paepe,

Kathleen Claes

Publication year - 2008

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2007.098764

Subject(s) - high resolution melt , amplicon , biology , temperature gradient gel electrophoresis , resolution (logic) , coding region , microbiology and biotechnology , exon , polymerase chain reaction , genetics , 16s ribosomal rna , gene , computer science , artificial intelligence

High-resolution melting is an emerging technique for detection of nucleic acid sequence variations. Developments in instrumentation and saturating intercalating dyes have made accurate high-resolution melting analysis possible and created opportunities to use this technology in diagnostic settings. We evaluated 2 high-resolution melting instruments for screening BRCA1 and BRCA2 mutations.

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