Free Thyroid Hormones in Serum by Direct Equilibrium Dialysis and Online Solid-Phase Extraction–Liquid Chromatography/Tandem Mass Spectrometry | Zendy

Bingfang Yue | Zendy; Alan L. Rockwood | Zendy; Tanya Sandrock | Zendy; Sonia L. La’ulu | Zendy; Mark M. Kushnir | Zendy; A.W. Meikle | Zendy

Open Access

Free Thyroid Hormones in Serum by Direct Equilibrium Dialysis and Online Solid-Phase Extraction–Liquid Chromatography/Tandem Mass Spectrometry

Author(s) -

Bingfang Yue,

Alan L. Rockwood,

Tanya Sandrock,

Sonia L. La’ulu,

Mark M. Kushnir,

A.W. Meikle

Publication year - 2008

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2007.098293

Subject(s) - chromatography , chemistry , liquid chromatography–mass spectrometry , solid phase extraction , detection limit , triiodothyronine , tandem mass spectrometry , immunoassay , mass spectrometry , dialysis , free thyroxine , extraction (chemistry) , ion suppression in liquid chromatography–mass spectrometry , hormone , medicine , antibody , thyroid function , immunology , biochemistry

Measurements of free thyroxine (FT4) and free triiodothyronine (FT3) are important for the diagnosis and monitoring of thyroid diseases. Considerable differences among methods limit their clinical utility, however, and accurate methods are needed for various clinical specimens. We describe a direct equilibrium dialysis (ED)-liquid chromatography (LC)/tandem mass spectrometry (MS/MS) method for FT4 and FT3.

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