Two-Dimensional Gas Chromatography/Electron-Impact Mass Spectrometry with Cryofocusing for Simultaneous Quantification of MDMA, MDA, HMMA, HMA, and MDEA in Human Plasma | Zendy

Erin A Kolbrich | Zendy; Ross H. Lowe | Zendy; Marilyn A. Huestis | Zendy

Open Access

Two-Dimensional Gas Chromatography/Electron-Impact Mass Spectrometry with Cryofocusing for Simultaneous Quantification of MDMA, MDA, HMMA, HMA, and MDEA in Human Plasma

Author(s) -

Erin A Kolbrich,

Ross H. Lowe,

Marilyn A. Huestis

Publication year - 2007

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2007.096800

Subject(s) - chromatography , chemistry , analyte , mdma , detection limit , selected ion monitoring , gas chromatography , ecstasy , gas chromatography–mass spectrometry , solid phase extraction , mass spectrometry , pharmacokinetics , calibration curve , extraction (chemistry) , pharmacology , medicine , sociology , anthropology

3,4-Methylenedioxymethamphetamine (MDMA, or Ecstasy) is a popular recreational drug. Analysis of MDMA and metabolites in human plasma, particularly in pharmacokinetic studies, requires low limits of quantification. Two-dimensional GC/MS with cryofocusing is a chromatographic technique recognized for its increased selectivity and resolution.

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