Association of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mutation/Variant/Haplotype and Tumor Necrosis Factor (TNF) Promoter Polymorphism in Hyperlipidemic Pancreatitis | Zendy

YuTing Chang | Zendy; MingChu Chang | Zendy; TaChen Su | Zendy; PoChin Liang | Zendy; YiNing Su | Zendy; Chun-Hung Kuo | Zendy; ShuChen Wei | Zendy; JauMin Wong | Zendy

Open Access

Association of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Mutation/Variant/Haplotype and Tumor Necrosis Factor (TNF) Promoter Polymorphism in Hyperlipidemic Pancreatitis

Author(s) -

YuTing Chang,

MingChu Chang,

TaChen Su,

PoChin Liang,

YiNing Su,

Chun-Hung Kuo,

ShuChen Wei,

JauMin Wong

Publication year - 2007

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2007.093492

Subject(s) - cystic fibrosis transmembrane conductance regulator , trypsinogen , microbiology and biotechnology , biology , pancreatitis , pancreatic disease , cancer research , cystic fibrosis , medicine , endocrinology , trypsin , genetics , pancreas , biochemistry , enzyme

The mechanism by which hypertriglyceridemia (HTG) leads to pancreatitis is not clear. We sought to determine whether the genes involved in pancreatic ductal or acinar cell injury, including the cationic trypsinogen gene [protease, serine, 1 (trypsin 1) (PRSS1)], the pancreatic secretory trypsin inhibitor gene [serine peptidase inhibitor, Kazal type 1 (SPINK1)], the cystic fibrosis transmembrane conductance regulator gene [cystic fibrosis transmembrane conductance regulator (ATP-binding cassette subfamily C, member 7) (CFTR)], and inflammation genes such as tumor necrosis factor [tumor necrosis factor, TNF superfamily, member 2 (TNF)] are associated with hyperlipidemic pancreatitis (HLP) in patients with HTG.

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