Specific Magnetic Bead–Based Capture of Genomic DNA from Clinical Samples: Application to the Detection of Group B Streptococci in Vaginal/Anal Swabs | Zendy

Nicholas J. Parham | Zendy; François J. Picard | Zendy; Régis Peytavi | Zendy; Martin Gag | Zendy; Grégoire Seyrig | Zendy; P Gagné | Zendy; Maurice Boissinot | Zendy; Michel G. Bergeron | Zendy

Open Access

Specific Magnetic Bead–Based Capture of Genomic DNA from Clinical Samples: Application to the Detection of Group B Streptococci in Vaginal/Anal Swabs

Author(s) -

Nicholas J. Parham,

François J. Picard,

Régis Peytavi,

Martin Gag,

Grégoire Seyrig,

P Gagné,

Maurice Boissinot,

Michel G. Bergeron

Publication year - 2007

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2007.091389

Subject(s) - oligonucleotide , hybridization probe , genomic dna , dna , dna extraction , biology , microbiology and biotechnology , polymerase chain reaction , genetics , gene

Group B streptococci (GBS) are a leading cause of sepsis and meningitis in newborns. We previously developed a rapid diagnostic system for GBS detection from vaginal/anal samples obtained from pregnant women during delivery. To facilitate the adaptation of this method for point-of-care testing, we have developed a specific and efficient GBS DNA capture method that is compatible with both PCR and nonamplification detection technologies.

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