Open AccessDetailed Technical Analysis of Urine RNA-Based Tumor Diagnostics Reveals ETS2/Urokinase Plasminogen Activator to Be a Novel Marker for Bladder Cancer
Author(s) -
Merle Hanke,
Ingo Kausch,
Gerlinde Dahmen,
D. Jocham,
Jens M. Warnecke
Publication year - 2007
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2007.091363
Subject(s) - urine , bladder cancer , rna , oncogene , cancer , urinary system , cancer research , tumor marker , medicine , plasminogen activator , messenger rna , microbiology and biotechnology , biology , pathology , gene , cell cycle , biochemistry
The noninvasive detection of RNA tumor markers in body fluids represents an attractive diagnostic option, but diagnostic performance of tissue-derived markers is often poorer when measured in body fluids rather than in tumors. We aimed to develop a procedure for measurement of tumor RNA in urine that would minimize donor-dependent influences on the results.
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