Mass Spectrometry: A Tool for Enhanced Detection of Hemoglobin Variants | Zendy

P. Kleinert | Zendy; Marlis Schmid | Zendy; Karin Zurbriggen | Zendy; Oliver Speer | Zendy; Markus Schmugge | Zendy; Bernd Roschitzki | Zendy; Silke Durka | Zendy; Urs Leopold | Zendy; Thomas Küster | Zendy; Claus W. Heizmann | Zendy; Hannes Frischknecht | Zendy; Heinz Troxler | Zendy

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Mass Spectrometry: A Tool for Enhanced Detection of Hemoglobin Variants

Author(s) -

P. Kleinert,

Marlis Schmid,

Karin Zurbriggen,

Oliver Speer,

Markus Schmugge,

Bernd Roschitzki,

Silke Durka,

Urs Leopold,

Thomas Küster,

Claus W. Heizmann,

Hannes Frischknecht,

Heinz Troxler

Publication year - 2007

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2007.089961

Subject(s) - hemoglobin variants , chromatography , mass spectrometry , chemistry , electrospray ionization , hemoglobin , thalassemia , high performance liquid chromatography , globin , genetics , biology , biochemistry

More than 900 hemoglobin (Hb) variants are currently known. Common techniques used in Hb analysis are electrophoretic and chromatographic assays. In our laboratory, we routinely apply chromatographic methods. To ascertain whether Hb variants are missed with our procedures, we additionally analyzed all samples with mass spectrometry (MS).

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