P-Selectin–Coated Microtube for Enrichment of CD34+ Hematopoietic Stem and Progenitor Cells from Human Bone Marrow | Zendy

Srinivas D. Narasipura | Zendy; Joel C. Wojciechowski | Zendy; Nichola Charles | Zendy; Jane L. Liesveld | Zendy; Michael R. King | Zendy

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P-Selectin–Coated Microtube for Enrichment of CD34+ Hematopoietic Stem and Progenitor Cells from Human Bone Marrow

Author(s) -

Srinivas D. Narasipura,

Joel C. Wojciechowski,

Nichola Charles,

Jane L. Liesveld,

Michael R. King

Publication year - 2007

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2007.089896

Subject(s) - cd34 , bone marrow , progenitor cell , haematopoiesis , stem cell , chemistry , microbiology and biotechnology , immunology , biology

Enrichment and purification of hematopoietic stem and progenitor cells (HSPCs) is important in transplantation therapies for hematologic disorders and in basic stem cell research. Primitive CD34+ HSPCs have demonstrated stronger rolling adhesion on selectins than mature CD34- mononuclear cells (MNCs). We have exploited this differential rolling behavior to capture and purify HSPCs from bone marrow by perfusing MNCs through selectin-coated microtubes.

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