Detection of Amplifiable mRNA Extracellular to Insulin-Producing Cells: Potential for Predicting Beta Cell Mass and Function | Zendy

Sweta Rani | Zendy; Martin Clynes | Zendy; Lorraine O’Driscoll | Zendy

Open Access

Detection of Amplifiable mRNA Extracellular to Insulin-Producing Cells: Potential for Predicting Beta Cell Mass and Function

Author(s) -

Sweta Rani,

Martin Clynes,

Lorraine O’Driscoll

Publication year - 2007

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2007.087973

Subject(s) - extracellular , cell culture , biology , messenger rna , microbiology and biotechnology , beta cell , intracellular , cell , insulin , biochemistry , islet , gene , endocrinology , genetics

Detecting extracellular nucleic acids in the serum/plasma of cancer patients may help in cancer diagnosis. We investigated whether extracellular mRNAs are reproducibly detectable in conditioned medium (CM) from insulin-producing cell cultures and if their presence and amounts are indicative of cell number and/or function.

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