Open AccessT-Cell Regulatory Gene CTLA-4 Polymorphism/Haplotype Association with Autoimmune Pancreatitis
Author(s) -
MingChu Chang,
YuTing Chang,
YuWen Tien,
PoChin Liang,
IShiow Jan,
ShuChen Wei,
JauMin Wong
Publication year - 2007
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2007.085951
Subject(s) - haplotype , autoimmune pancreatitis , gene , pancreatitis , polymorphism (computer science) , genetics , ctla 4 , genetic association , immunology , biology , medicine , allele , t cell , single nucleotide polymorphism , genotype , immune system
Autoimmune pancreatitis (AIP) is a distinct disease entity of chronic pancreatitis. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a key negative regulator of the T-cell immune response, and its gene is highly polymorphic. Many positive associations between cytotoxic T-lymphocyte-associated protein 4 (CTLA4) single-nucleotide polymorphisms and various autoimmune diseases have been identified. We investigated possible genetic associations of CTLA4 in a Chinese population with AIP.
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