Standardization of ROC Curve Areas for Diagnostic Evaluation of Liver Fibrosis Markers Based on Prevalences of Fibrosis Stages | Zendy

Thierry Poynard | Zendy; Philippe Halfon | Zendy; Laurent Castéra | Zendy; M. Munteanu | Zendy; Françoise ImbertBismut | Zendy; Vlad Ratziu | Zendy; Y. Benhamou | Zendy; Marc Bourlière | Zendy; Victor de Lédinghen | Zendy

Open Access

Standardization of ROC Curve Areas for Diagnostic Evaluation of Liver Fibrosis Markers Based on Prevalences of Fibrosis Stages

Author(s) -

Thierry Poynard,

Philippe Halfon,

Laurent Castéra,

M. Munteanu,

Françoise ImbertBismut,

Vlad Ratziu,

Y. Benhamou,

Marc Bourlière,

Victor de Lédinghen

Publication year - 2007

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2007.085795

Subject(s) - medicine , fibrosis , receiver operating characteristic , stage (stratigraphy) , area under the curve , population , gastroenterology , pathology , biology , paleontology , environmental health

The area under the ROC curve (AUC) is widely used as an estimate of the diagnostic value for fibrosis markers. Whether there is variability in the AUC related to the prevalence of fibrosis stages defining advanced and nonadvanced fibrosis is unknown. The aim of this study was to assess the relationships between the AUC and the prevalence of each fibrosis stage and to elaborate simple methods of standardization.

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