Growth Hormone (GH) Receptor Isoform in Acromegaly: Lower Concentrations of GH but Not Insulin-Like Growth Factor-1 in Patients with a Genomic Deletion of Exon 3 in the GH Receptor Gene | Zendy

Christoph Schmid | Zendy; PierreAlexandre Krayenbuehl | Zendy; René-Ludwig Bernays | Zendy; Cornelia Zwimpfer | Zendy; Friedrich E. Maly | Zendy; Peter Wiesli | Zendy

Open Access

Growth Hormone (GH) Receptor Isoform in Acromegaly: Lower Concentrations of GH but Not Insulin-Like Growth Factor-1 in Patients with a Genomic Deletion of Exon 3 in the GH Receptor Gene

Author(s) -

Christoph Schmid,

PierreAlexandre Krayenbuehl,

René-Ludwig Bernays,

Cornelia Zwimpfer,

Friedrich E. Maly,

Peter Wiesli

Publication year - 2007

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2007.085712

Subject(s) - growth hormone receptor , acromegaly , medicine , endocrinology , basal (medicine) , genotype , insulin like growth factor , exon , biology , growth hormone , receptor , growth factor , insulin , hormone , gene , genetics

A genomic deletion of exon 3 (d3-GHR) of the growth hormone (GH) receptor (GHR) has been linked to the effectiveness of GH therapy in children with GH deficiency. Carriers of the d3-GHR genotype had higher GH-induced growth rates than children homozygous for the full-length (fl)-GHR. The aim of this study was to test whether the relationship between GH and insulin-like growth factor-1 (IGF-1) concentrations is influenced by the GHR genotype in patients with acromegaly.

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