High-Throughput Quantitative Profiling of Serum N-Glycome by MALDI-TOF Mass Spectrometry and N-Glycomic Fingerprint of Liver Fibrosis | Zendy

Richard KT Kam | Zendy; Terence CW Poon | Zendy; Henry LY Chan | Zendy; Nathalie Wong | Zendy; Alex Hui | Zendy; Joseph J.�Y. Sung | Zendy

Open Access

High-Throughput Quantitative Profiling of Serum N-Glycome by MALDI-TOF Mass Spectrometry and N-Glycomic Fingerprint of Liver Fibrosis

Author(s) -

Richard KT Kam,

Terence CW Poon,

Henry LY Chan,

Nathalie Wong,

Alex Hui,

Joseph J.�Y. Sung

Publication year - 2007

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2007.085563

Subject(s) - glycome , cirrhosis , fibrosis , mass spectrometry , glycan , chemistry , glycomics , medicine , chromatography , pathology , glycoprotein , biochemistry

The use of MALDI-TOF mass spectrometry (MS) in quantitative glycan profiling has not been reported. In this study, we attempted to establish a high-throughput quantitative assay for profiling serum N-glycome, and we applied the new assay to identifying serum N-glycans for diagnosis of liver fibrosis and cirrhosis.

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