Large Fluctuations in Parathyroid Hormone Concentrations After Autotransplantation of Parathyroid Tissue in the Forearm | Zendy

Jasper A. Remijn | Zendy; J.R. Beukhof | Zendy; L.D. Dikkeschei | Zendy

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Large Fluctuations in Parathyroid Hormone Concentrations After Autotransplantation of Parathyroid Tissue in the Forearm

Author(s) -

Jasper A. Remijn,

J.R. Beukhof,

L.D. Dikkeschei

Publication year - 2007

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2006.083667

Subject(s) - autotransplantation , forearm , parathyroid hormone , medicine , endocrinology , surgery , calcium , transplantation

Hyperparathyroidism is a potentially serious complication in patients with advanced renal insufficiency (1). As renal mass dwindles and phosphate excretion gets more difficult, synthesis of 1,25-dihydroxycholecalciferol is impaired, and concentrations of fibroblast growth factor-23 increase (2), leading to low serum calcium concentrations and an initially appropriate response of the parathyroids: parathyroid hormone (PTH) synthesis increases. Subsequently, however, parathyroid hypertrophy gradually develops. After a period of time, the calcium-sensing receptor is reset, the calcium × phosphate product increases, soft tissues and vessels become calcified, and …

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