Open AccessQuantitative Mitochondrial DNA Mutation Analysis by Denaturing HPLC
Author(s) -
Kok Seong Lim,
Robert K. Naviaux,
Richard Haas
Publication year - 2007
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2006.083303
Subject(s) - heteroduplex , mitochondrial dna , mutant , mutation , denaturing high performance liquid chromatography , microbiology and biotechnology , biology , genetics , dna , gene
In recent years, denaturing HPLC (DHPLC) has been widely used to screen the whole mitochondrial genome or specific regions of the genome for DNA mutations. The quantification and mathematical modeling of DHPLC results is, however, underexplored.
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