Aptamers Evolved from Cultured Cancer Cells Reveal Molecular Differences of Cancer Cells in Patient Samples | Zendy

Dihua Shangguan | Zendy; Zehui Cao | Zendy; Ying Li | Zendy; Weihong Tan | Zendy

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Aptamers Evolved from Cultured Cancer Cells Reveal Molecular Differences of Cancer Cells in Patient Samples

Author(s) -

Dihua Shangguan,

Zehui Cao,

Ying Li,

Weihong Tan

Publication year - 2007

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2006.083246

Subject(s) - aptamer , cell culture , neoplastic cell , systematic evolution of ligands by exponential enrichment , microbiology and biotechnology , cancer cell , biology , cell , lymphoma , jurkat cells , molecular probe , flow cytometry , leukemia , cancer research , chemistry , cancer , t cell , biochemistry , dna , rna , immunology , genetics , gene , immune system

Molecular-level differentiation of neoplastic cells is essential for accurate and early diagnosis, but effective molecular probes for molecular analysis and profiling of neoplastic cells are not yet available. We recently developed a cell-based SELEX (systematic evolution of ligands by exponential enrichment) strategy to generate aptamers (designer DNA/RNA probes) as molecular probes to recognize neoplastic cells.

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