Diagnostic Accuracy of Blood Lactate-to-Pyruvate Molar Ratio in the Differential Diagnosis of Congenital Lactic Acidosis | Zendy

FrançoisGuillaume Debray | Zendy; Grant A. Mitchell | Zendy; Pierre Allard | Zendy; Brian H. Robinson | Zendy; James A. Hanley | Zendy; Marie Lambert | Zendy

Open Access

Diagnostic Accuracy of Blood Lactate-to-Pyruvate Molar Ratio in the Differential Diagnosis of Congenital Lactic Acidosis

Author(s) -

FrançoisGuillaume Debray,

Grant A. Mitchell,

Pierre Allard,

Brian H. Robinson,

James A. Hanley,

Marie Lambert

Publication year - 2007

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2006.081166

Subject(s) - lactic acidosis , medicine , lactate dehydrogenase , lactic acid , acidosis , molar ratio , gastroenterology , mole , l lactate dehydrogenase , endocrinology , biochemistry , biology , enzyme , bacteria , genetics , catalysis

Although the blood lactate-to-pyruvate (L:P) molar ratio is used to distinguish between pyruvate dehydrogenase deficiency (PDH-D) and other causes of congenital lactic acidosis (CLA), its diagnostic accuracy for differentiating between these 2 types of CLA has not been evaluated formally.

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