Multiplex Genotyping of Cytochrome P450 Single-Nucleotide Polymorphisms by Use of MALDI-TOF Mass Spectrometry | Zendy

Ashish Misra | Zendy; Jun-Yan Hong | Zendy; Sobin Kim | Zendy

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Multiplex Genotyping of Cytochrome P450 Single-Nucleotide Polymorphisms by Use of MALDI-TOF Mass Spectrometry

Author(s) -

Ashish Misra,

Jun-Yan Hong,

Sobin Kim

Publication year - 2007

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2006.080739

Subject(s) - genotyping , multiplex , mass spectrometry , single nucleotide polymorphism , chemistry , genotype , chromatography , genetics , biology , biochemistry , gene

Polymorphisms in cytochrome P450 (CYP450) genes contribute to interindividual differences in the metabolism of xenobiotic chemicals, including the vast majority of drugs, and may lead to toxicity and adverse drug reactions. Studies on these polymorphisms in research and diagnostic settings typically involve large-scale genotyping and hence require high-throughput assays.

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