A Strong Interaction between Serum γ-Glutamyltransferase and Obesity on the Risk of Prevalent Type 2 Diabetes: Results from the Third National Health and Nutrition Examination Survey | Zendy

Ji-Sun Lim | Zendy; DukHee Lee | Zendy; Joo-Yun Park | Zendy; Soo-Hee Jin | Zendy; David R. Jacobs | Zendy

Open Access

A Strong Interaction between Serum γ-Glutamyltransferase and Obesity on the Risk of Prevalent Type 2 Diabetes: Results from the Third National Health and Nutrition Examination Survey

Author(s) -

Ji-Sun Lim,

DukHee Lee,

Joo-Yun Park,

Soo-Hee Jin,

David R. Jacobs

Publication year - 2007

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2006.079814

Subject(s) - national health and nutrition examination survey , obesity , health examination , medicine , type 2 diabetes , diabetes mellitus , endocrinology , environmental health , gerontology , population

Some studies have found an association of obesity with type 2 diabetes only among individuals with high normal serum gamma-glutamyltransferase (GGT) activity, not in those with low serum GGT. If this interaction reflected pathophysiology, it would have scientific and clinical importance. The findings failed to reach statistical significance, however, and no articles have focused on the topic. We investigated possible interactions between serum GGT and body mass index (BMI) and their effects on the risk of prevalent type 2 diabetes and homeostasis model assessment (HOMA) insulin resistance.

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