Multiple Fluorescent Labeling of Silica Nanoparticles with Lanthanide Chelates for Highly Sensitive Time-Resolved Immunofluorometric Assays | Zendy

Ye Xu | Zendy; Qingge Li | Zendy

Open Access

Multiple Fluorescent Labeling of Silica Nanoparticles with Lanthanide Chelates for Highly Sensitive Time-Resolved Immunofluorometric Assays

Author(s) -

Ye Xu,

Qingge Li

Publication year - 2007

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2006.078485

Subject(s) - detection limit , lanthanide , hbsag , nanoparticle , conjugate , chelation , conjugated system , covalent bond , chemistry , fluorescence , nuclear chemistry , hbeag , materials science , chromatography , nanotechnology , hepatitis b virus , virology , polymer , inorganic chemistry , organic chemistry , medicine , virus , ion , mathematical analysis , mathematics , physics , quantum mechanics

Time-resolved immunofluorometric assays (TrIFA) using lanthanide-labeled nanoparticles have greatly increased the sensitivity of immunoassays. Current labeling strategies, however, use either physical doping of lanthanide chelates into preformed nanoparticles or covalent linking of lanthanide chelates to precursors used for making nanoparticles; both these strategies have drawbacks.

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