Mutant-Enriched PCR and Allele-Specific Hybridization Reaction to Detect K-ras Mutations in Stool DNA: High Prevalence in a Large Sample of Older Adults | Zendy

Ulrike Haug | Zendy; Timo Hillebrand | Zendy; Peter Bendzkô | Zendy; Michael Löw | Zendy; Dietrich Rothenbacher | Zendy; Christa Stegmaier | Zendy; Hermann Brenner | Zendy

Open Access

Mutant-Enriched PCR and Allele-Specific Hybridization Reaction to Detect K-ras Mutations in Stool DNA: High Prevalence in a Large Sample of Older Adults

Author(s) -

Ulrike Haug,

Timo Hillebrand,

Peter Bendzkô,

Michael Löw,

Dietrich Rothenbacher,

Christa Stegmaier,

Hermann Brenner

Publication year - 2007

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2006.078188

Subject(s) - allele , polymerase chain reaction , microbiology and biotechnology , biology , mutant , genetics , dna , gene

Testing for mutant K-ras in stool has been proposed for the detection of pancreatic and colorectal cancer (CRC). Different analytical techniques have been developed, but studies of this biomarker in the general population are lacking. We investigated the prevalence and potential determinants of mutant K-ras in stool in a large sample of unselected older adults and assessed the association with colonoscopic findings.

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