Multiplexed Proteomic Analysis of Oxidation and Concentrations of Cerebrospinal Fluid Proteins in Alzheimer Disease | Zendy

Minna A. Korolainen | Zendy; Tuula A. Nyman | Zendy; Paula Nyyssönen | Zendy; Samuel Hartikainen | Zendy; Tuula Pirttilä | Zendy

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Multiplexed Proteomic Analysis of Oxidation and Concentrations of Cerebrospinal Fluid Proteins in Alzheimer Disease

Author(s) -

Minna A. Korolainen,

Tuula A. Nyman,

Paula Nyyssönen,

Samuel Hartikainen,

Tuula Pirttilä

Publication year - 2007

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2006.078014

Subject(s) - protein carbonylation , oxidative stress , cerebrospinal fluid , carbonylation , alzheimer's disease , cognitive decline , chemistry , oxidative phosphorylation , dementia , medicine , endocrinology , biochemistry , disease , lipid peroxidation , carbon monoxide , catalysis

Carbonylation is an irreversible oxidative modification of proteins that has been linked to various conditions of oxidative stress, aging, physiological disorders, and disease. Increased oxidative stress is thus also considered to play a role in the pathogenesis of age-related neurodegenerative disorders such as Alzheimer disease (AD). In addition, it has recently become evident that the response mechanisms to increased oxidative stress may depend on sex. Several oxidized carbonylated proteins have been identified in plasma and brain of AD patients by use of 2-dimensional oxyblotting.

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