Open AccessProcessing-Independent Quantitation of Chromogranin A in Plasma from Patients with Neuroendocrine Tumors and Small-Cell Lung Carcinomas
Author(s) -
Tine Børglum,
Jens F. Rehfeld,
L. Drivsholm,
Linda Hilsted
Publication year - 2007
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2006.076158
Subject(s) - chromogranin a , neuroendocrine tumors , lung , biology , medicine , pathology , endocrinology , immunohistochemistry
Most neuroendocrine tumors express chromogranin A (CgA). The posttranslational processing of neuroendocrine proteins such as CgA is often specific for the individual tumor. To cope with this variability and improve tumor diagnosis, we developed a processing-independent analysis (PIA) method to measure the total CgA product.
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