Cell-Free Fetal DNA in Amniotic Fluid: Unique Fragmentation Signatures in Euploid and Aneuploid Fetuses | Zendy

Olav Lapaire | Zendy; Diana W. Bianchi | Zendy; Inga Peter | Zendy; Barbara O’Brien | Zendy; Helene Stroh | Zendy; Janet M. Cowan | Zendy; Umadevi Tantravahi | Zendy; Kirby L. Johnson | Zendy

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Cell-Free Fetal DNA in Amniotic Fluid: Unique Fragmentation Signatures in Euploid and Aneuploid Fetuses

Author(s) -

Olav Lapaire,

Diana W. Bianchi,

Inga Peter,

Barbara O’Brien,

Helene Stroh,

Janet M. Cowan,

Umadevi Tantravahi,

Kirby L. Johnson

Publication year - 2007

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2006.076083

Subject(s) - cell free fetal dna , aneuploidy , fetus , amniotic fluid , andrology , trisomy , ploidy , monosomy , gestational age , amniocentesis , karyotype , biology , prenatal diagnosis , medicine , pregnancy , genetics , chromosome , gene

Circulating cell-free fetal deoxyribonucleic acids (cffDNA) are novel biomarkers with many clinical applications. Amniotic fluid (AF) is a rich source of cffDNA. We investigated the biophysical characteristics of cffDNA in AF, hypothesizing that they would differ from cffDNA in maternal plasma.

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