Hypermethylated RASSF1A in Maternal Plasma: A Universal Fetal DNA Marker that Improves the Reliability of Noninvasive Prenatal Diagnosis | Zendy

K.C. Allen Chan | Zendy; Chunming Ding | Zendy; Ageliki Gerovassili | Zendy; Sze Wan Yeung | Zendy; Rossa W. K. Chiu | Zendy; Tse Ngong Leung | Zendy; Tze Kin Lau | Zendy; S Chim | Zendy; Grace TY Chung | Zendy; K. H. Nicolaides | Zendy; YM Dennis Lo | Zendy

Open Access

Hypermethylated RASSF1A in Maternal Plasma: A Universal Fetal DNA Marker that Improves the Reliability of Noninvasive Prenatal Diagnosis

Author(s) -

K.C. Allen Chan,

Chunming Ding,

Ageliki Gerovassili,

Sze Wan Yeung,

Rossa W. K. Chiu,

Tse Ngong Leung,

Tze Kin Lau,

S Chim,

Grace TY Chung,

K. H. Nicolaides,

YM Dennis Lo

Publication year - 2006

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2006.074997

Subject(s) - fetus , cell free fetal dna , dna methylation , prenatal diagnosis , genotyping , methylation , genotype , andrology , biology , pregnancy , placenta , microbiology and biotechnology , medicine , dna , gene , genetics , gene expression

We recently demonstrated that the promoter of the RASSF1A gene is hypermethylated in the placenta and hypomethylated in maternal blood cells. This methylation pattern allows the use of methylation-sensitive restriction enzyme digestion for detecting the placental-derived hypermethylated RASSF1A sequences in maternal plasma.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research