Use of Routinely Collected Amniotic Fluid for Whole-Genome Expression Analysis of Polygenic Disorders | Zendy

G Nagy | Zendy; Balázs Győrffy | Zendy; Orsolya Galamb | Zendy; Béla Péter Molnár | Zendy; Bálint Nagy | Zendy; Zoltán Papp | Zendy

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Use of Routinely Collected Amniotic Fluid for Whole-Genome Expression Analysis of Polygenic Disorders

Author(s) -

G Nagy,

Balázs Győrffy,

Orsolya Galamb,

Béla Péter Molnár,

Bálint Nagy,

Zoltán Papp

Publication year - 2006

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2006.074971

Subject(s) - neural tube , amniotic fluid , amniocentesis , neural tube defect , gene , biology , dna microarray , microarray , fetus , prenatal diagnosis , genetics , gene expression , genome , bioinformatics , pregnancy , embryo

Neural tube defects related to polygenic disorders are the second most common birth defects in the world, but no molecular biologic tests are available to analyze the genes involved in the pathomechanism of these disorders. We explored the use of routinely collected amniotic fluid to characterize the differential gene expression profiles of polygenic disorders.

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