MALDI-TOF Mass Spectrometry for Multiplex Genotyping of CYP2B6 Single-Nucleotide Polymorphisms | Zendy

Julia Blievernicht | Zendy; Elke Schaeffeler | Zendy; Kathrin Klein | Zendy; Michel Eichelbaum | Zendy; Matthias Schwab | Zendy; Ulrich M. Zanger | Zendy

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MALDI-TOF Mass Spectrometry for Multiplex Genotyping of CYP2B6 Single-Nucleotide Polymorphisms

Author(s) -

Julia Blievernicht,

Elke Schaeffeler,

Kathrin Klein,

Michel Eichelbaum,

Matthias Schwab,

Ulrich M. Zanger

Publication year - 2006

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2006.074856

Subject(s) - single nucleotide polymorphism , genotyping , snp genotyping , microbiology and biotechnology , genotype , multiplex , multiplex polymerase chain reaction , biology , chemistry , genetics , polymerase chain reaction , gene

CYP2B6 is a highly variable and polymorphic cytochrome P450 (CYP) enzyme involved in the biotransformation of an increasing number of drugs, including cyclophosphamide, bupropion, and the nonnucleosidic reverse transcriptase inhibitor efavirenz. Several nonsynonymous and promoter single-nucleotide polymorphisms (SNPs) in the CYP2B6 gene are associated with altered hepatic expression and function, which affect drug plasma concentrations.

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