Factors Affecting S-Homocysteinylation of LDL Apoprotein B | Zendy

Angelo Zinellu | Zendy; Elisabetta Zinellu | Zendy; Salvatore Sotgia | Zendy; Marilena Formato | Zendy; Gian Mario Cherchi | Zendy; Luca Deiana | Zendy; Ciriaco Carru | Zendy

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Factors Affecting S-Homocysteinylation of LDL Apoprotein B

Author(s) -

Angelo Zinellu,

Elisabetta Zinellu,

Salvatore Sotgia,

Marilena Formato,

Gian Mario Cherchi,

Luca Deiana,

Ciriaco Carru

Publication year - 2006

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2006.071142

Subject(s) - apolipoprotein b , homocysteine , chemistry , medicine , hyperhomocysteinemia , endocrinology , glutathione , cysteine , lipoprotein , endothelial dysfunction , cholesterol , biochemistry , enzyme

Hyperhomocysteinemia is an important risk factor for vascular disease and atherosclerosis, but the mechanisms by which homocysteine exerts its deleterious effects are not known. Because oxidation and/or homocysteinylation may increase atherogenicity of LDL, we investigated S-homocysteinylation of LDL as a possible contributor to atherosclerosis pathogenesis.

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