Connective Tissue Growth Factor in Serum as a New Candidate Test for Assessment of Hepatic Fibrosis | Zendy

Axel M. Gressner | Zendy; Eray Yagmur | Zendy; Birgit Lahme | Zendy; O Gressner | Zendy; S Stanzel | Zendy

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Connective Tissue Growth Factor in Serum as a New Candidate Test for Assessment of Hepatic Fibrosis

Author(s) -

Axel M. Gressner,

Eray Yagmur,

Birgit Lahme,

O Gressner,

S Stanzel

Publication year - 2006

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2006.070466

Subject(s) - ctgf , cirrhosis , fibrosis , connective tissue , medicine , growth factor , gastroenterology , hepatic fibrosis , viral hepatitis , pathology , receptor

No reliable, cost-effective serum test is available for assessment of liver fibrogenesis, the most serious complication of chronic inflammatory liver diseases (CLD). In sera of patients with CLD, we determined the concentration of connective tissue growth factor (CTGF), a secreted downstream mediator of the potent fibrogenic cytokine transforming growth factor beta (TGF-beta).

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