Rapid Screening of 4000 Individuals for Germ-line Variations in the BRAF Gene | Zendy

Michael R. James | Zendy; Troy Dumeni | Zendy; Mitchell Stark | Zendy; David L. Duffy | Zendy; Grant W. Montgomery | Zendy; Nicholas G. Martin | Zendy; Nicholas K. Hayward | Zendy

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Rapid Screening of 4000 Individuals for Germ-line Variations in the BRAF Gene

Author(s) -

Michael R. James,

Troy Dumeni,

Mitchell Stark,

David L. Duffy,

Grant W. Montgomery,

Nicholas G. Martin,

Nicholas K. Hayward

Publication year - 2006

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2006.070169

Subject(s) - melanoma , germline , valine , germline mutation , biology , gene , cancer research , genetics , somatic cell , microbiology and biotechnology , mutation , amino acid

The BRAF gene is frequently somatically altered in malignant melanoma. A majority of variations are at the valine 600 residue leading to a V600E substitution that constitutively activates the kinase. We screened 4000 patient and control DNAs for germ-line variations at the valine 600 residue.

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