Development and Performance Evaluation of a Tandem Mass Spectrometry Assay for 4 Adrenal Steroids | Zendy

Mark M. Kushnir | Zendy; Alan L. Rockwood | Zendy; William L. Roberts | Zendy; Elizabeth G Pattison | Zendy; William E. Owen | Zendy; Ashley M. Bunker | Zendy; A.W. Meikle | Zendy

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Development and Performance Evaluation of a Tandem Mass Spectrometry Assay for 4 Adrenal Steroids

Author(s) -

Mark M. Kushnir,

Alan L. Rockwood,

William L. Roberts,

Elizabeth G Pattison,

William E. Owen,

Ashley M. Bunker,

A.W. Meikle

Publication year - 2006

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2006.068445

Subject(s) - pregnenolone , detection limit , congenital adrenal hyperplasia , electrospray ionization , tandem mass spectrometry , chromatography , chemistry , steroid , selected reaction monitoring , mass spectrometry , endocrinology , enzyme , medicine , solid phase extraction , hormone , biochemistry

Congenital adrenal hyperplasia is a group of autosomal recessive disorders caused by a deficiency of 1 of 4 enzymes required for the synthesis of glucocorticoids, mineralocorticoids, and sex hormones. Analysis of 11-deoxycortisol (11DC), 17-hydroxyprogesterone (17OHP), 17-hydroxypregnenolone (17OHPr), and pregnenolone (Pr) in blood allows detection of these enzyme defects.

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