Matrix-Assisted Laser Desorption/Ionization Mass Spectrometric Analysis of DNA on Microarrays | Zendy

Pamela Kepper | Zendy; Richard Reinhardt | Zendy; Andreas Dahl | Zendy; Hans Lehrach | Zendy; Sascha Sauer | Zendy

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Matrix-Assisted Laser Desorption/Ionization Mass Spectrometric Analysis of DNA on Microarrays

Author(s) -

Pamela Kepper,

Richard Reinhardt,

Andreas Dahl,

Hans Lehrach,

Sascha Sauer

Publication year - 2006

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2006.067264

Subject(s) - mass spectrometry , oligonucleotide , genotyping , chemistry , chromatography , matrix assisted laser desorption/ionization , dna microarray , nucleic acid , matrix (chemical analysis) , dna , analytical chemistry (journal) , desorption , genotype , gene , biochemistry , gene expression , organic chemistry , adsorption

Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry is a powerful tool in biomolecule analysis with a wide range of application possibilities, including genotyping of single-base variations (also known as single-nucleotide polymorphisms, or SNPs) for candidate gene studies and diagnostic typing of DNA markers. We tested a method that does not require stringent purification of the nucleic acids and/or the use of modification chemistry before mass spectrometry analysis.

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