Detection of a Soluble Form of BACE-1 in Human Cerebrospinal Fluid by a Sensitive Activity Assay | Zendy

Jan H. Verheijen | Zendy; L.G.M. Huisman | Zendy; Natascha van Lent | Zendy; Ulf Neumann | Zendy; Paolo Paganetti | Zendy; C. Erik Hack | Zendy; Femke H. Bouwman | Zendy; J. Lindeman | Zendy; Edward Bollen | Zendy; Roeland Hanemaaijer | Zendy

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Detection of a Soluble Form of BACE-1 in Human Cerebrospinal Fluid by a Sensitive Activity Assay

Author(s) -

Jan H. Verheijen,

L.G.M. Huisman,

Natascha van Lent,

Ulf Neumann,

Paolo Paganetti,

C. Erik Hack,

Femke H. Bouwman,

J. Lindeman,

Edward Bollen,

Roeland Hanemaaijer

Publication year - 2006

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2006.066720

Subject(s) - chemistry , biochemistry , peptide , proteases , neurodegeneration , protease , cleavage (geology) , amyloid precursor protein , enzyme , cerebrospinal fluid , blot , in vivo , alzheimer's disease , biology , medicine , paleontology , microbiology and biotechnology , disease , pathology , neuroscience , fracture (geology) , gene

Formation of deposits of the insoluble amyloid beta-peptide is believed to be causally related with neurodegeneration in Alzheimer disease (AD). The beta-peptide originates from a larger amyloid precursor protein (APP) by the action of proteolytic enzymes. The first proteolytic event leading to amyloid formation is the cleavage of APP by the membrane-bound aspartyl protease BACE-1, also known as memapsin-2. Inhibition of BACE-1 is thought to be a therapeutic approach to AD. Measuring BACE-1 activity in biological samples would be useful to elucidate the mechanism of AD and for development of AD drugs.

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