Tumor Necrosis Factor-α −308G&gt;A Allelic Variant Modulates Iron Accumulation in Patients with Hereditary Hemochromatosis | Zendy

PierreAlexandre Krayenbuehl | Zendy; Friedrich E. Maly | Zendy; Martin Hersberger | Zendy; Peter Wiesli | Zendy; Andreas Himmelmann | Zendy; Karim Eid | Zendy; P Greminger | Zendy; W. Vetter | Zendy; Georg Schulthess | Zendy

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Tumor Necrosis Factor-α −308G>A Allelic Variant Modulates Iron Accumulation in Patients with Hereditary Hemochromatosis

Author(s) -

PierreAlexandre Krayenbuehl,

Friedrich E. Maly,

Martin Hersberger,

Peter Wiesli,

Andreas Himmelmann,

Karim Eid,

P Greminger,

W. Vetter,

Georg Schulthess

Publication year - 2006

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2005.065417

Subject(s) - hemochromatosis , hereditary hemochromatosis , allele , medicine , endocrinology , phlebotomy , alpha (finance) , tumor necrosis factor alpha , body mass index , biology , genetics , surgery , gene , construct validity , patient satisfaction

In vitro and animal studies suggest that tumor necrosis factor alpha (TNF-alpha) modulates intestinal iron transport. We hypothesized that the effect of TNF-alpha might be particularly relevant if iron absorption is not effectively controlled by the HFE gene.

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