Analytical Performance and Diagnostic Accuracy of Immunometric Assays for the Measurement of Circulating Oxidized LDL | Zendy

Paul Holvoet | Zendy; Elizabeth Macy | Zendy; Michèle Landeloos | Zendy; Dan Jones | Zendy; Jenny S Nancy | Zendy; Frans Van de Werf | Zendy; Russell P. Tracy | Zendy

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Analytical Performance and Diagnostic Accuracy of Immunometric Assays for the Measurement of Circulating Oxidized LDL

Author(s) -

Paul Holvoet,

Elizabeth Macy,

Michèle Landeloos,

Dan Jones,

Jenny S Nancy,

Frans Van de Werf,

Russell P. Tracy

Publication year - 2006

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2005.064337

Subject(s) - confidence interval , logistic regression , coronary heart disease , medicine , analysis of variance , odds ratio , ldl cholesterol , pathogenesis , cholesterol , gastroenterology

Oxidized LDL (ox-LDL) plays an important role in the pathogenesis of coronary heart disease (CHD). Several tests for circulating ox-LDL have been published. We believe it is critical to carefully evaluate these assays because small differences in performance may have profound effects when results are compared; we therefore compared the analytical and clinical performances of 2 assays: one developed in our laboratory and a commercial assay (Mercodia) that uses the same monoclonal antibody (4E6).

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