Adipocyte Fatty Acid–Binding Protein Is a Plasma Biomarker Closely Associated with Obesity and Metabolic Syndrome
Author(s) -
Aimin Xu,
Yu Wang,
Jian Xu,
David Stejskal,
Sidney Tam,
Jialiang Zhang,
Nelson M.S. Wat,
Wai Keung Wong,
Karen SL Lam
Publication year - 2006
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2005.062463
Subject(s) - medicine , endocrinology , insulin resistance , metabolic syndrome , body mass index , obesity , biomarker , fatty acid binding protein , dyslipidemia , overweight , waist , adipocyte , biology , adipose tissue , biochemistry , gene
Adipocyte fatty acid-binding protein (A-FABP) is traditionally thought to be a cytosolic fatty acid chaperone expressed in adipocytes. Mice with targeted disruption of the A-FABP gene exhibit a striking phenotype with strong protection from insulin resistance, hyperglycemia, and atherosclerosis. The clinical relevance of these findings remains to be confirmed.
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