Measurement of Total Vitamin B12 and Holotranscobalamin, Singly and in Combination, in Screening for Metabolic Vitamin B12 Deficiency | Zendy

Joshua W. Miller | Zendy; Marjorie G Garrod | Zendy; Alan L. Rockwood | Zendy; Mark M. Kushnir | Zendy; Lindsay H. Allen | Zendy; Mary N. Haan | Zendy; Ralph Green | Zendy

Open Access

Measurement of Total Vitamin B12 and Holotranscobalamin, Singly and in Combination, in Screening for Metabolic Vitamin B12 Deficiency

Author(s) -

Joshua W. Miller,

Marjorie G Garrod,

Alan L. Rockwood,

Mark M. Kushnir,

Lindsay H. Allen,

Mary N. Haan,

Ralph Green

Publication year - 2005

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2005.061382

Subject(s) - methylmalonic acid , vitamin b12 , homocysteine , medicine , cobalamin , endocrinology , cyanocobalamin , vitamin , b vitamins

The standard screening test for vitamin B12 deficiency, measurement of total plasma vitamin B12, has limitations of sensitivity and specificity. Plasma vitamin B12 bound to transcobalamin (holoTC) is the fraction of total vitamin B12 available for tissue uptake and therefore has been proposed as a potentially useful alternative indicator of vitamin B12 status.

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