Open AccessAllele Dropout in PCR-Based Diagnosis of Wilson Disease: Mechanisms and Solutions
Author(s) -
ChingWan Lam,
Chloe Miu Mak
Publication year - 2006
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2005.060491
Subject(s) - allele , genetics , biology , primer (cosmetics) , exon , polymerase chain reaction , proofreading , genomic dna , mutation , gene , microbiology and biotechnology , population , variants of pcr , single nucleotide polymorphism , genotype , polymerase , medicine , chemistry , environmental health , organic chemistry
We investigated the mechanisms leading to allele dropout-the nonamplification of 1 of the alleles-in PCR-based diagnosis of Wilson disease (WD).
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