Immunoassays Developed for Pregnancy-Associated Plasma Protein-A (PAPP-A) in Pregnancy May Not Recognize PAPP-A in Acute Coronary Syndromes | Zendy

Qiuping Qin | Zendy; Saara Kokkala | Zendy; Juha Lund | Zendy; Natalia N Tamm | Zendy; Xuezhong Qin | Zendy; Mauri Lepäntalo | Zendy; Kim Pettersson | Zendy

Open Access

Immunoassays Developed for Pregnancy-Associated Plasma Protein-A (PAPP-A) in Pregnancy May Not Recognize PAPP-A in Acute Coronary Syndromes

Author(s) -

Qiuping Qin,

Saara Kokkala,

Juha Lund,

Natalia N Tamm,

Xuezhong Qin,

Mauri Lepäntalo,

Kim Pettersson

Publication year - 2006

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2005.058396

Subject(s) - pregnancy associated plasma protein a , monoclonal antibody , antibody , major basic protein , epitope , pregnancy , monoclonal , immunology , medicine , eosinophil , biology , gestation , asthma , genetics , first trimester

Pregnancy-associated plasma protein-A (PAPP-A) concentrations are increased in the circulation of patients with acute coronary syndromes (ACS) and are associated with future adverse cardiac events. PAPP-A in ACS differs from PAPP-A in pregnancy in that PAPP-A in ACS is not complexed with the proform of eosinophil major basic protein (proMBP). We investigated the effect of antibody selection on the utility of PAPP-A assays for measurement of PAPP-A in pregnancy and/or ACS, and whether immunoassays for PAPP-A in pregnancy are suitable for PAPP-A in ACS.

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