Open AccessFeasibility Study of the Use of Frozen Human Sera in Split-Sample Comparison of Immunoassays with Candidate Reference Measurement Procedures for Total Thyroxine and Total Triiodothyronine Measurements
Author(s) -
Linda M. Thienpont,
Katleen Van Uytfanghe,
John Marriott,
Peter E. Stokes,
Lothar Siekmann,
Anja Keßler,
David M. Bunk,
Susan S.-C. Tai
Publication year - 2005
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2005.058180
Subject(s) - triiodothyronine , chromatography , sample (material) , reference values , free thyroxine , chemistry , medicine , thyroid , thyroid function
Diagnostic manufacturers must ensure/document metrologically traceable assays. We report on a feasibility study of a split-sample comparison for that purpose. Processed, frozen single-donation sera, assigned target values by candidate reference measurement procedures (cRMPs), were used with immunoassays for total thyroxine (TT(4)) and triiodothyronine (TT(3)) as models.
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