Effect of l-Carnitine on Acetyl-CoA Content and Activity of Blood Platelets in Healthy and Diabetic Persons | Zendy

Anna Michno | Zendy; Anna RaszejaSpecht | Zendy; Agnieszka Jankowska-Kulawy | Zendy; Tadeusz Pawełczyk | Zendy; Andrzej Szutowicz | Zendy

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Effect of l-Carnitine on Acetyl-CoA Content and Activity of Blood Platelets in Healthy and Diabetic Persons

Author(s) -

Anna Michno,

Anna RaszejaSpecht,

Agnieszka Jankowska-Kulawy,

Tadeusz Pawełczyk,

Andrzej Szutowicz

Publication year - 2005

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2005.050328

Subject(s) - platelet , carnitine , endocrinology , medicine , diabetes mellitus , fructosamine , metabolism , chemistry

Excessive blood platelet activity contributes to vascular complications in diabetic persons. Increased acetyl-CoA in platelets from diabetic persons has been suggested to be a cause of this hyperactivity. We therefore investigated whether L-carnitine, which up-regulates metabolism of acetyl-CoA in muscles and brain, may affect platelet function in healthy and diabetic individuals.

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