The CAG Repeat Polymorphism in the Androgen Receptor Gene Is Associated with HDL-Cholesterol but Not with Coronary Atherosclerosis or Myocardial Infarction | Zendy

Martin Hersberger | Zendy; Jörg Muntwyler | Zendy; Harald Funke | Zendy; Jacqueline Marti-Jaun | Zendy; H. Schulte | Zendy; Gerd Assmann | Zendy; Thomas F. Lüscher | Zendy; Arnold von Eckardstein | Zendy

Open Access

The CAG Repeat Polymorphism in the Androgen Receptor Gene Is Associated with HDL-Cholesterol but Not with Coronary Atherosclerosis or Myocardial Infarction

Author(s) -

Martin Hersberger,

Jörg Muntwyler,

Harald Funke,

Jacqueline Marti-Jaun,

H. Schulte,

Gerd Assmann,

Thomas F. Lüscher,

Arnold von Eckardstein

Publication year - 2005

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2005.049262

Subject(s) - medicine , odds ratio , myocardial infarction , endocrinology , androgen receptor , confidence interval , body mass index , allele , androgen , lower risk , cholesterol , biology , gene , genetics , prostate cancer , cancer , hormone

Age-adjusted morbidity and mortality rates from coronary heart disease (CHD) are higher in men than in women. Androgens are suspected to be responsible for the male disadvantage. The genomic effect of androgens is mediated by the androgen receptor (AR), which has a polymorphic CAG repeat in exon 1. The number of repeats is inversely related to the transcriptional activity of the AR on target genes.

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