Endothelial Nitric Oxide Synthase −786T&gt;C, but Not 894G&gt;T and 4a4b, Polymorphism Influences Plasma Homocysteine Concentrations in Persons with Normal Vitamin Status | Zendy

Cinzia Fatini | Zendy; Francesco Sofi | Zendy; Anna Maria Gori | Zendy; Elena Sticchi | Zendy; Rossella Marcucci | Zendy; Meri Lenti | Zendy; Alessandro Casini | Zendy; C. Surrenti | Zendy; Rosanna Abbate | Zendy; Gian Franco Gensini | Zendy

Open Access

Endothelial Nitric Oxide Synthase −786T>C, but Not 894G>T and 4a4b, Polymorphism Influences Plasma Homocysteine Concentrations in Persons with Normal Vitamin Status

Author(s) -

Cinzia Fatini,

Francesco Sofi,

Anna Maria Gori,

Elena Sticchi,

Rossella Marcucci,

Meri Lenti,

Alessandro Casini,

C. Surrenti,

Rosanna Abbate,

Gian Franco Gensini

Publication year - 2005

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2005.048850

Subject(s) - medicine , methylenetetrahydrofolate reductase , homocysteine , endocrinology , enos , odds ratio , vitamin , biology , chemistry , nitric oxide synthase , nitric oxide , biochemistry , genotype , gene

Nitric oxide (NO) plays a relevant role in various events during atherogenesis. In vitro data suggest that NO may modulate homocysteine (Hcy) concentrations. The aim of this study was to investigate the role of endothelial nitric oxide synthase (eNOS) -786T>C, 894G>T, and 4a4b polymorphisms in influencing Hcy concentrations.

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