Quantification of Mycophenolic Acid and Glucuronide Metabolite in Human Serum by HPLC-Tandem Mass Spectrometry | Zendy

Thomas M Annesley | Zendy; Larry Clayton | Zendy

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Quantification of Mycophenolic Acid and Glucuronide Metabolite in Human Serum by HPLC-Tandem Mass Spectrometry

Author(s) -

Thomas M Annesley,

Larry Clayton

Publication year - 2005

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2004.047357

Subject(s) - chromatography , chemistry , high performance liquid chromatography , tandem mass spectrometry , mass spectrometry , glucuronide , mycophenolic acid , metabolite , solid phase extraction , electrospray ionization , extraction (chemistry) , selected reaction monitoring , transplantation , biochemistry , medicine , surgery

The potent immunosuppressant mycophenolic acid (MPA) is metabolized to an inactive glucuronide (MPAG). The extent of metabolism varies among individuals, and the MPAG formed can be hydrolyzed to MPA and can displace MPA from serum albumin, creating a potential need to monitor both MPA and MPAG.

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