Stable-Isotope Dilution Liquid Chromatography–Electrospray Injection Tandem Mass Spectrometry Method for Fast, Selective Measurement of S-Adenosylmethionine and S-Adenosylhomocysteine in Plasma | Zendy

Henkjan Gellekink | Zendy; Dinny van Oppenraaij-Emmerzaal | Zendy; Arno van Rooij | Zendy; Eduard A. Struys | Zendy; Martin den Heijer | Zendy; Henk J. Blom | Zendy

Open Access

Stable-Isotope Dilution Liquid Chromatography–Electrospray Injection Tandem Mass Spectrometry Method for Fast, Selective Measurement of S-Adenosylmethionine and S-Adenosylhomocysteine in Plasma

Author(s) -

Henkjan Gellekink,

Dinny van Oppenraaij-Emmerzaal,

Arno van Rooij,

Eduard A. Struys,

Martin den Heijer,

Henk J. Blom

Publication year - 2005

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2004.046995

Subject(s) - chromatography , isotope dilution , chemistry , liquid chromatography–mass spectrometry , tandem mass spectrometry , electrospray , mass spectrometry , selected reaction monitoring , electrospray mass spectrometry

It has been postulated that changes in S-adenosylhomocysteine (AdoHcy), a potent inhibitor of transmethylation, provide a mechanism by which increased homocysteine causes its detrimental effects. We aimed to develop a rapid and sensitive method to measure AdoHcy and its precursor S-adenosylmethionine (AdoMet).

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