Fast and Slow Skeletal Troponin I in Serum from Patients with Various Skeletal Muscle Disorders: A Pilot Study | Zendy

Jeremy A. Simpson | Zendy; Ralf Labugger | Zendy; Christine E Collier | Zendy; Robert J. Brison | Zendy; Steve Iscoe | Zendy; Jennifer E. Van Eyk | Zendy

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Fast and Slow Skeletal Troponin I in Serum from Patients with Various Skeletal Muscle Disorders: A Pilot Study

Author(s) -

Jeremy A. Simpson,

Ralf Labugger,

Christine E Collier,

Robert J. Brison,

Steve Iscoe,

Jennifer E. Van Eyk

Publication year - 2005

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2004.042671

Subject(s) - skeletal muscle , gene isoform , troponin , troponin i , blot , cardiac muscle , biology , proteolysis , biochemistry , medicine , endocrinology , enzyme , gene , myocardial infarction

Detection of skeletal muscle injury is hampered by a lack of commercially available assays for serum markers specific for skeletal muscle; serum concentrations of skeletal troponin I (sTnI) could meet this need. Moreover, because sTnI exists in 2 isoforms, slow (ssTnI) and fast (fsTnI), corresponding to slow- and fast-twitch muscles, respectively, it could provide insight into differential injury/recovery of specific fiber types. The purpose of this study was to investigate whether the 2 isoforms of sTnI and their modified forms are present in the blood of patients with various skeletal muscle disorders.

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