Open AccessQuantification of Antimalarial Bisthiazolium Compounds and Their Neutral Bioprecursors in Plasma by Liquid Chromatography-Electrospray Mass Spectrometry
Author(s) -
Olivier Nicolas,
Christine Farenc,
Michèle Calas,
Henri Vial,
Françoise Bressolle
Publication year - 2005
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2004.042580
Subject(s) - chromatography , mass spectrometry , chemistry , electrospray mass spectrometry , electrospray , liquid chromatography–mass spectrometry
A new class of antimalarial drugs targeting membrane biogenesis during intraerythrocytic Plasmodium falciparum development has been identified. The bisthiazolium salts T3 and T4 have superior in vitro and in vivo parasite-killing properties and need to be monitored.
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