Relationship between In Vitro Lipopolysaccharide-Induced Cytokine Response in Whole Blood, Angiographic In-Stent Restenosis, and Toll-Like Receptor 4 Gene Polymorphisms
Author(s) -
Saskia Z.H. Rittersma,
Johanna A. Kremer Hovinga,
Karel T. Koch,
S. Matthijs Boekholdt,
Benien E. van Aken,
Arko Scheepmaker,
Matthijs Bax,
Carl E. Schotborgh,
Jan J. Piek,
Jan G.P. Tijssen,
Pieter H. Reitsma,
Robbert J. de Winter
Publication year - 2005
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2004.041277
Subject(s) - restenosis , medicine , cytokine , unstable angina , tlr4 , stent , genotype , cardiology , inflammation , gastroenterology , immunology , myocardial infarction , biology , gene , biochemistry
In coronary in-stent restenosis (ISR), a substantial contribution of inflammation is assumed. We evaluated the association between polymorphisms in the Toll-like receptor 4 (TLR4) gene and cytokine response after lipopolysaccharide (LPS) challenge and the development of ISR.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom